Background The objective of the current study was to investigate both short- and long-term outcomes of patients undergoing curative-intent resection for intrahepatic cholangiocarcinoma (ICC) stratified by extent of hepatic resection relative to overall final pathological margin status.
Methods One thousand twenty-three patients with ICC who underwent curative-intent resection were identified from a multiinstitutional database. Demographic, clinicopathological, and operative data, as well as overall (OS) and recurrence-free survival (RFS) were compared among patients undergoing major and minor resection before and after propensity score matching.
Results Overall, 608 patients underwent major hepatectomy, while 415 had aminor resection.Major hepatectomy was more frequently performed among patients who had large, multiple, and bilobar tumors. Roughly half of patients developed a postoperative complication following major hepatectomy versus only one fourth of patients after minor resection. In the propensity model, patients who underwent major hepatectomy had an equivalent OS and RFS versus patients who had a minor hepatectomy. Patients undergoing major resection had comparable OS and RFS with wide surgical margin, but improved RFS when surgical margin was narrow versus minor resection in the propensity model. In the Cox regression model, tumor characteristics and surgical margin were independently associated with long-term outcome.
Conclusions Major hepatectomy for ICC was not associated with an overall survival benefit, yet was associated with increased perioperative morbidity. Margin width, rather than the extent of resection, affected long-term outcomes. Radical parenchymalsparing resection should be advocated if a margin clearance of ≥5 mm can be achieved.

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Keywords Hepatectomy, Intrahepatic cholangiocarcinoma, Major, Minor, Outcomes
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Journal Journal of Gastrointestinal Surgery
Zhang, X.-F. (Xu-Feng), Bagante, F, Chakedis, J. (Jeffery), Moris, D. (Dimitrios), Beal, E, Weiss, M, … Pawlik, T.M. (2017). Perioperative and Long-Term Outcome for Intrahepatic Cholangiocarcinoma: Impact of Major Versus Minor Hepatectomy. Journal of Gastrointestinal Surgery, 1–10. doi:10.1007/s11605-017-3499-6