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H. Chi (Heng), Wong, D. (David), J. Peng (Jie), J. Cao (Jiawei), Van Hees, S. (Stijn), T. Vanwolleghem (Thomas), Qi, X. (Xun), Chen, L. (Liang), J.J. Feld (Jordan J.), R.J. de Knegt (Robert), et al. B.E. Hansen (Bettina) and H.L.A. Janssen (Harry)

2017-08-15

Durability of Response after Hepatitis B Surface Antigen Seroclearance during Nucleos(t)ide Analogue Treatment in a Multiethnic Cohort of Chronic Hepatitis B Patients: Results after Treatment Cessation

Publication

Publication

Clinical Infectious Diseases , Volume 65 - Issue 4 p. 680- 683

In 70 chronic hepatitis B patients with hepatitis B surface antigen seroclearance during nucleos(t)ide analogue therapy, response was sustained in all 54 patients who discontinued treatment. Clinically significant relapses as indicated by high hepatitis B virus DNA and ALT levels were not observed. Anti-HBs positivity may not be required to ensure sustained off-treatment response.

Additional Metadata
Keywords chronic hepatitis B, HBsAg negative, nucleos(t)ide analogue, off-treatment response, treatment discontinuation
Persistent URL doi.org/10.1093/cid/cix353, hdl.handle.net/1765/101053
Journal Clinical Infectious Diseases
Organisation Department of Gastroenterology & Hepatology
Citation
Chi, H., Wong, D. (David), Peng, J., Cao, J., Van Hees, S. (Stijn), Vanwolleghem, T., … Janssen, H. (2017). Durability of Response after Hepatitis B Surface Antigen Seroclearance during Nucleos(t)ide Analogue Treatment in a Multiethnic Cohort of Chronic Hepatitis B Patients: Results after Treatment Cessation. Clinical Infectious Diseases, 65(4), 680–683. doi:10.1093/cid/cix353


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