In 70 chronic hepatitis B patients with hepatitis B surface antigen seroclearance during nucleos(t)ide analogue therapy, response was sustained in all 54 patients who discontinued treatment. Clinically significant relapses as indicated by high hepatitis B virus DNA and ALT levels were not observed. Anti-HBs positivity may not be required to ensure sustained off-treatment response.

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Keywords chronic hepatitis B, HBsAg negative, nucleos(t)ide analogue, off-treatment response, treatment discontinuation
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Journal Clinical Infectious Diseases
Chi, H, Wong, D. (David), Peng, J, Cao, J, Van Hees, S. (Stijn), Vanwolleghem, T, … Janssen, H.L.A. (2017). Durability of Response after Hepatitis B Surface Antigen Seroclearance during Nucleos(t)ide Analogue Treatment in a Multiethnic Cohort of Chronic Hepatitis B Patients: Results after Treatment Cessation. Clinical Infectious Diseases, 65(4), 680–683. doi:10.1093/cid/cix353