Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes
Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal ﬂuid.The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be conﬁrmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.
|Persistent URL||dx.doi.org/10.1002/acn3.396, hdl.handle.net/1765/101277|
|Journal||Annals of Clinical and Translational Neurology|
van Coevorden-Hameete, M.H, van Beuningen, S.F.B, Perrenoud, M. (Matthieu), Will, L, Hulsenboom, E, Demonet, J.-F. (Jean-Francois), … Hoogenraad, C.C. (2017). Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes. Annals of Clinical and Translational Neurology. doi:10.1002/acn3.396