Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury
Nutritionele en cellulaire preconditionering tegen ischemie-reperfusie schade
We investigated the impact of donor type on transcriptional changes that occur after organ retrieval and cold storage in kidneys and livers from living donors, DCD and DBD donors.
Further studies describe the use of nutritional preconditioning and infusion of mesenchymal stem cells as possible treatments to ameliorate IRI.
Finally, a mouse model with reduced expression of Fibulin-4 was used to study the local and systemic effects of renal IRI in short- and long-term.
|Keywords||Ischemia reperfusion injury, dietary restriction, fasting, mesenchymal stem cells, fibulin-4, inflammatory genes, living donor, donation after brain death, donation after cardiac death|
|Promotor||J.N.M. IJzermans (Jan) , R.W.F. de Bruin (Ron)|
|Publisher||Erasmus University Rotterdam|
Saat, T.C. (2017, September 22). Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/101490