We investigated the impact of donor type on transcriptional changes that occur after organ retrieval and cold storage in kidneys and livers from living donors, DCD and DBD donors.
Further studies describe the use of nutritional preconditioning and infusion of mesenchymal stem cells as possible treatments to ameliorate IRI.
Finally, a mouse model with reduced expression of Fibulin-4 was used to study the local and systemic effects of renal IRI in short- and long-term.

Additional Metadata
Keywords Ischemia reperfusion injury, dietary restriction, fasting, mesenchymal stem cells, fibulin-4, inflammatory genes, living donor, donation after brain death, donation after cardiac death
Promotor J.N.M. IJzermans (Jan) , R.W.F. de Bruin (Ron)
Publisher Erasmus University Rotterdam
ISBN 978-94-92683-67-0
Persistent URL hdl.handle.net/1765/101490
Citation
Saat, T.C. (2017, September 22). Nutritional and Cellular Preconditioning in Ischemia-reperfusion Injury. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/101490