2016-07-01
Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS
Publication
Publication
Annals of Clinical and Translational Neurology p. 547- 551
Treatment of Guillain-Barré syndrome with a standard course of high-dose intravenous immunoglobulin (IVIg) results in a variable clinical recovery which is associated with changes in serum IgG levels after treatment. The neonatal Fc-receptor protects IgG from degradation, and a genetic polymorphism in its promoter region that influences the expression of Fc-receptor, may in part explain the variation in IgG levels and outcome. This polymorphism was determined by polymerase chain reaction in a cohort of 257 patients with Guillain-Barré syndrome treated with IVIg. We could not demonstrate a relation between this polymorphism, the pharmacokinetics of IVIg, or the clinical course and outcome.
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| doi.org/10.1002/acn3.307, hdl.handle.net/1765/101581 | |
| Annals of Clinical and Translational Neurology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Fokkink, W.-J., Haarman, A.E.G. (Annechien E. G.), Tio-Gillen, A., van Rijs, W., Huizinga, R., van Doorn, P., & Jacobs, B. (2016). Neonatal Fc receptor promoter gene polymorphism does not predict pharmacokinetics of IVIg or the clinical course of GBS. Annals of Clinical and Translational Neurology, 547–551. doi:10.1002/acn3.307 |
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