Objective Acute pancreatitis may be the first manifestation of pancreatic cancer. The aim of this study was to assess the risk of pancreatic cancer after a first episode of acute pancreatitis. Methods Between March 2004 and March 2007, all consecutive patients with a first episode of acute pancreatitis were prospectively registered. Follow-up was based on hospital records audit, radiological imaging, and patient questionnaires. Outcome was stratified based on the development of chronic pancreatitis. Results We included 731 patients. The median follow-up time was 55 months. Progression to chronic pancreatitis was diagnosed in 51 patients (7.0%). In this group, the incidence rate per 1000 person-years for developing pancreatic cancer was 9.0 (95% confidence interval, 2.3-35.7). In the group of 680 patients who did not develop chronic pancreatitis, the incidence rate per 1000 person-years for developing pancreatic cancer in this group was 1.1 (95% confidence interval, 0.3-3.3). Hence, the rate ratio of pancreatic cancer was almost 9 times higher in patients who developed chronic pancreatitis compared with those who did not (P = 0.049). Conclusions Although a first episode of acute pancreatitis may be related to pancreatic cancer, this risk is mainly present in patients who progress to chronic pancreatitis.

Additional Metadata
Keywords acute pancreatitis, malignancy, pancreas, pancreatic cancer
Persistent URL dx.doi.org/10.1097/MPA.0000000000000879, hdl.handle.net/1765/101640
Journal Pancreas
Rijkers, A.P, Bakker, O.J, Ali, U.A, Hagenaars, J.C.J.P, van Santvoort, H.C, Besselink, M.G, … van Eijck, C.H.J. (2017). Risk of Pancreatic Cancer after a Primary Episode of Acute Pancreatitis. Pancreas, 46(8), 1018–1022. doi:10.1097/MPA.0000000000000879