The cause of PHACE syndrome is unknown. In a study of 218 patients, we examined potential prenatal risk factors for PHACE syndrome. Rates of pre-eclampsia and placenta previa in affected individuals were significantly greater than in the general population. No significant risk factor differences were detected between male and female subjects.

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Keywords Disease pathogenesis, Hemangioma, Perinatal risk factors
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Journal Journal of Pediatrics
Wan, J. (Joy), Steiner, J. (Jack), Baselga, E, Blei, F. (Francine), Cordisco, M. (Maria), Garzon, M.C. (Maria C.), … Siegel, D. (2017). Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository. Journal of Pediatrics. doi:10.1016/j.jpeds.2017.06.055