The cause of PHACE syndrome is unknown. In a study of 218 patients, we examined potential prenatal risk factors for PHACE syndrome. Rates of pre-eclampsia and placenta previa in affected individuals were significantly greater than in the general population. No significant risk factor differences were detected between male and female subjects.

Additional Metadata
Keywords Disease pathogenesis, Hemangioma, Perinatal risk factors
Persistent URL dx.doi.org/10.1016/j.jpeds.2017.06.055, hdl.handle.net/1765/101701
Journal Journal of Pediatrics
Citation
Wan, J. (Joy), Steiner, J. (Jack), Baselga, E, Blei, F. (Francine), Cordisco, M. (Maria), Garzon, M.C. (Maria C.), … Siegel, D. (2017). Prenatal Risk Factors for PHACE Syndrome: A Study Using the PHACE Syndrome International Clinical Registry and Genetic Repository. Journal of Pediatrics. doi:10.1016/j.jpeds.2017.06.055