Purpose: To describe a rare clinical case of biopsy-proven metastatic mesothelioma of the lacrimal gland which responded well to chemo and radiation therapy. Methods: Interventional case report. Results: A 55-year-old woman with an untreated malignant biopsy-proven pleural mesothelioma presented with right proptosis, diplopia and hypoglobus. Magnetic resonance imaging showed an aggressive lacrimal gland tumour with bony erosion. A biopsy concluded a diagnosis of metastatic mesothelioma of the lacrimal gland. Her lacrimal and lung tumours showed a marked regression following palliative chemo (carboplatin) and radiation therapy. Conclusions: Malignant pleural mesothelioma may metastasize to the orbit, including the lacrimal gland. A combined chemo and radiation therapy may reduce the size of the metastatic and primary tumour.

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doi.org/10.1111/aos.13163, hdl.handle.net/1765/101757
Acta Ophthalmologica
Erasmus MC: University Medical Center Rotterdam

Hanafi, H., Verdijk, R., & Paridaens, D. (2016). Malignant pleural mesothelioma with lacrimal gland metastasis. Acta Ophthalmologica, 94(8), 836–838. doi:10.1111/aos.13163