HBV and HCV infection are the two leading causes of chronic liver inflammation worldwide, affecting an approximate 370–390 million people. Currently, the viral and immunological mechanisms that underlie either the resolution or persistence of viral hepatitis infections are not fully understood. Investigation and identification of the integral components in the host immune responses that cumulatively lead to the effective clearance of the virus or development of a chronic infection are of the utmost importance. Therefore, the overall aim of this thesis was to understand the function, and dysfunction, of specific aspects of the innate immune system in the resolution or persistence of viral hepatitis infection. The two main components of the immune response focused on in this thesis were the roles IFNs, specifically type I and III IFNs, and NK cells play in determining disease state and outcome.

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H.J. Metselaar (Herold) , P.A. Boonstra (André)
Erasmus University Rotterdam
Department of Gastroenterology & Hepatology

de Groen, R. (2017, October 10). Understanding the Innate Immune Response in Viral Hepatitis : Interferons and NK Cells. Retrieved from http://hdl.handle.net/1765/101848