The foreign body reaction differs per biomaterial and per patient. Some patients have complications after implantation of a biomaterial and some have none with the same biomaterial. For clinical practice, it would be a great benefit to have a tailor-made model with patients own cells to test pre-operatively which biomaterial is best thereby reducing complication rates. Since most of the knowledge and use of biomaterials is in general surgery, we will focus our research in this field. The ultimate goal of our research is to develop a tailor-made in vitro model with human macrophages.

Towards developing this model, the following aims are formulated:
1) to develop an in vitro model to study the effect of biomaterials on human macrophage polarisation
2) to investigate the influence of biomaterials on macrophage phenotype in an inflammatory environment and whether this is biomaterial-dependent
3) to investigate the influence of biomaterials on stem cells and macrophages together in an adjusted in vitro model

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The studies described in this thesis were financially supported by Medtronics (Covidien- Sofradim), NWO Domain Applied and Engineering Sciences (TTW, previously Technology Foundation STW), Ethicon, B.Braun, Bard, Dutch Arthritis Association (LLP11)
G.J.V.M. van Osch (Gerjo) , J.F. Lange (Johan) , Y.M. Bastiaansen-Jenniskens (Yvonne)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Retrieved from