Hyperthermia is an emerging cancer treatment modality, which involves applying heat to the malignant tumor. The heating can be delivered using electromagnetic (EM) energy, mostly in the radiofrequency (RF) or microwave range. Accurate patient-specific hyperthermia treatment planning (HTP) is essential for effective and safe treatments, in particular, for deep and loco-regional hyperthermia. An important aspect of HTP is the ability to focus microwave energy into the tumor and reduce the occurrence of hot spots in healthy tissue. This paper presents amethod for optimizing the specific absorption rate (SAR) distribution for the head and neck cancer hyperthermia treatment. The SAR quantifies the rate at which localized RF or microwave energy is absorbed by the biological tissuewhen exposed to an EM field. A differential evolution (DE) optimization algorithm is proposed in order to improve the SAR coverage of the target region. The efficacy of the proposed algorithm is demonstrated by testing with the Erasmus MC patient dataset. DE is compared to the particle swarm optimization (PSO) method, in terms of average performance and standard deviation and across various clinical metrics, such as the hot-spot-tumor SAR quotient (HTQ), treatment quantifiers, and temperature parameters. While hot spots in the SAR distribution remain a problem with current approaches, DE enhances focusing microwave energy absorption to the target region during hyperthermia treatment. In particular, DE offers improved performance compared to the PSO algorithm currently deployed in the clinic, reporting a range of improvement of HTQ standard deviation of between 40.1-96.8% across six patients.

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Keywords Differential evolution (DE) algorithm, Hyperthermia, Hyperthermia treatment planning (HTP), Specific absorption rate (SAR)
Persistent URL dx.doi.org/10.1109/TBME.2016.2627941, hdl.handle.net/1765/101956
Journal I E E E Transactions on Biomedical Engineering
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Cappiello, G. (G.), McGinley, B. (B.), Elahi, M.A. (M. A.), Drizdal, T, Paulides, M.M, Glavin, M. (M.), … Jones, E. (E.). (2017). Differential evolution optimization of the SAR distribution for head and neck hyperthermia. I E E E Transactions on Biomedical Engineering, 64(8), 1875–1885. doi:10.1109/TBME.2016.2627941