Background Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor α for locally advanced angiosarcoma. Material and methods All patients who underwent an ILP for angiosarcomas between 1991 and 2016 in three tertiary referral centres were identified from prospectively maintained databases. Results A total of 39 patients were included, with a median follow-up of 18 months (interquartile range 6.1–60.8). Of these patients, 23 (58.9%) patients had a complete response (CR) after ILP, 10 (25.6%) had a partial response, 4 (10.3%) had stable disease and 2 (5.1%) patients had progressive disease immediately after ILP. A total of 22 patients developed local progression (56.4%), whereas nine (23.1%) developed distant metastases. The patients with CR had a significantly prolonged median local progression-free survival (PFS) (15.4 versus 7.3 months, p = 0.015) when compared with non-CR patients, and a trend towards better median overall survival (81.2 versus 14.5 months, p = 0.054). Six patients underwent multiple ILPs, whereby the CR rate of the first, second and third ILPs were 60%, 80% and 67%, respectively. Thirteen (33.3%) patients needed further surgical intervention, consisting of resection in eight patients (20.5%) and amputation in five patients (12.8%). Conclusion ILP is an effective treatment option for patients with locally advanced angiosarcoma in the extremities, resulting in a high number of CRs, a high limb salvage rate and prolonged local PFS.

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Keywords Angiosarcoma, Cutaneous angiosarcoma of the extremity, ILP, Isolated limb perfusion, Limb salvage technique, Locally advanced angiosarcoma, Sarcoma
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Journal European Journal of Cancer
Huis Veld, E.A. (E. A.), Grunhagen, D.J, Verhoef, C, Smith, H.G. (H. G.), van Akkooi, A.C.J, Jones, R. (R.), … van Houdt, W.J. (2017). Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study. European Journal of Cancer, 85, 114–121. doi:10.1016/j.ejca.2017.07.023