2017-09-15
Acute Toxicity of the bowel after stereotactic robotic radiotherapy for abdominopelvic oligometastases
Publication
Publication
Acta Oncologica p. 1- 5
Aim: To correlate dose-volume histogram (DVH) parameters with appearance of grade ≥2 acute and late gastrointestinal toxicity of stereotactic body radiotherapy (SBRT) in patients with abdominopelvic solitary or oligometastatic disease outside the liver. Material and methods: Acute and late bowel toxicity of 84 abdominopelvic oligometastatic patients was registered. A logistic regression was performed between different DVH parameters and presence of grade ≥2 acute and late toxicity. A Normal Tissue Complication Probability (NTCP) model was built with significant parameters to determine complication probabilities (CP). Results: Thirteen (15%) of 84 patients experienced of grade ≥2 acute toxicity, while 8 (10%) reported late toxicity complications. A significant relationship was found for EQD2 (V30Gy, V40Gy, V50Gy and V65Gy) and grade ≥2 acute toxicity. Dmax and D2 were not significant. Late grade ≥2 toxicity was not significantly correlated with any DVH parameter. According to our NTCP model for V40Gy, an irradiated bowel volume of 10 cm3 of V40Gy resulted in CP of grade ≥2 acute toxicity of less than 10%. Local control was 87% at 2 years and 82% at 5 years. Overall survival was 61% at 2 years and 32% at 5 years. Conclusions: After SBRT for abdominopelvic oligometastases, in general, the presence of acute and late toxicity was low. A significant relationship was found for V30Gy, V40Gy, V50Gy and V65Gy and grade ≥2 acute toxicity. We estimated acute complication probabilities per volume of irradiated bowel by V40Gy and V50Gy
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doi.org/10.1080/0284186X.2017.1378432, hdl.handle.net/1765/102046 | |
Acta Oncologica | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Frelinghuysen, M. (Michael), Schillemans, W., Hol, L., Verhoef, K., Hoogeman, M., & Nuyttens, J. (2017). Acute Toxicity of the bowel after stereotactic robotic radiotherapy for abdominopelvic oligometastases. Acta Oncologica, 1–5. doi:10.1080/0284186X.2017.1378432 |