Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppressive therapy. This review focuses on the pathophysiology and treatment of aplastic anaemia.
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| hdl.handle.net/1765/10206 | |
| The Netherlands Journal of Medicine | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Sleijfer, S., & Lugtenburg, P. (2003). Aplastic anaemia: a review. The Netherlands Journal of Medicine. Retrieved from http://hdl.handle.net/1765/10206 |
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