Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppressive therapy. This review focuses on the pathophysiology and treatment of aplastic anaemia.

The Netherlands Journal of Medicine
Erasmus MC: University Medical Center Rotterdam

Sleijfer, S., & Lugtenburg, P. (2003). Aplastic anaemia: a review. The Netherlands Journal of Medicine. Retrieved from http://hdl.handle.net/1765/10206