The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.

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Antimicrobial Agents and Chemotherapy
Erasmus MC: University Medical Center Rotterdam

Gerrits, M., Berning, M., van Vliet, A., Kuipers, E., & Kusters, J. (2003). Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori. Antimicrobial Agents and Chemotherapy. Retrieved from