The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.

, , , , , , ,
hdl.handle.net/1765/10211
Antimicrobial Agents and Chemotherapy
Erasmus MC: University Medical Center Rotterdam

Gerrits, M., Berning, M., van Vliet, A., Kuipers, E., & Kusters, J. (2003). Effects of 16S rRNA gene mutations on tetracycline resistance in Helicobacter pylori. Antimicrobial Agents and Chemotherapy. Retrieved from http://hdl.handle.net/1765/10211