2017-10-01
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Publication
Publication
Nature Reviews. Molecular Cell Biology , Volume 18 - Issue 10 p. 610- 621
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome integrity and leads to the development of various diseases, including cancer. Recent evidence has implicated poly(ADP-ribose) polymerase 1 (PARP1) in various DNA repair pathways and in the maintenance of genomic stability. The inhibition of PARP1 is therefore being exploited clinically for the treatment of various cancers, which include DNA repair-deficient ovarian, breast and prostate cancers. Understanding the role of PARP1 in maintaining genome integrity is not only important for the design of novel chemotherapeutic agents, but is also crucial for gaining insights into the mechanisms of chemoresistance in cancer cells. In this Review, we discuss the roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-strand break repair and the stabilization of replication forks, and in modulating chromatin structure.
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doi.org/10.1038/nrm.2017.53, hdl.handle.net/1765/102238 | |
Nature Reviews. Molecular Cell Biology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Ray Chaudhuri, A. (Arnab), & Nussenzweig, A. (2017). The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. Nature Reviews. Molecular Cell Biology (Vol. 18, pp. 610–621). doi:10.1038/nrm.2017.53 |