Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data: A case study in haemato-oncology
Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice development. This PBR + EHR approach opens a perspective on randomised registry trials.
|Keywords||Electronic health record, Evidence-based medicine, Haematology, Oncology, Population-based registry, Randomised clinical trial|
|Persistent URL||dx.doi.org/10.1016/j.ejca.2017.09.007, hdl.handle.net/1765/102279|
|Journal||European Journal of Cancer|
Kibbelaar, R.E. (R. E.), Oortgiesen, B.E. (B. E.), van der Wal-Oost, A.M. (A. M.), Boslooper, K. (K.), Coebergh, J.W.W, Veeger, N.J.G.M, … Hoogendoorn, M. (2017). Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data: A case study in haemato-oncology. European Journal of Cancer (Vol. 86, pp. 178–185). doi:10.1016/j.ejca.2017.09.007