Mental disorders are a major cause of disability among women during the perinatal period and have consequences for her unborn child as well. There is a lack of evidence-based treatment algorithms due to the complicated risk-benefit analysis for both mother and her unborn child. This thesis extends existing knowledge on the treatment and impact of mental disorders during pregnancy. It includes a meta-analysis on all pharmacological and non-pharmacological interventions to treat antepartum mental disorders. It evaluates the efficacy of a new group-based multicomponent therapy for pregnant women with a mental disorder. Subsequently, it explores the impact of a mental disorder on sleep quality by measuring objective and subjective sleep quality during pregnancy. Different phenotypes of mood fluctuations across pregnancy and associations with pregnancy outcomes are described. At last, the prevalence of suicidal ideation and deliberate self-harm is investigated in pregnant women with a severe mental disorder.

Additional Metadata
Keywords Pregnancy, mental disorder
Promotor W.J.G. Hoogendijk (Witte) , H.W. Tiemeier (Henning) , E.A.P. Steegers (Eric) , M.P. Lambregtse-van den Berg (Mijke)
Publisher Erasmus University Rotterdam
Sponsor The research in this thesis was financially supported by the Erasmus University Medical Center (MRACE Doelmatigheidsonderzoek 2009) and Stichting Coolsingel
ISBN 978-94-6233-671-1
Persistent URL
van Ravesteyn, L.M. (2017, October 18). Treatment and impact of mental disorders during pregnancy. Erasmus University Rotterdam. Retrieved from