The presence of porcine endogenous retroviruses presents a potential risk of transmission of infectious diseases (xenozoonosis) if tissues and organs from genetically modified pigs are to be used in xenotransplantation. Here, we report that intracellular expression of a llama single-domain antibody against p15, the matrix domain protein of the porcine endogenous retrovirus Gag polyprotein, blocks retrovirus production, providing the possibility of eliminating the risk of infection in xenotransplantation.

, , , , , , , , , , , , , , , , ,
Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Dekker, S., Toussaint, W., Panayotou, G., Visser, P., Drabek, D., Grosveld, F., & de Wit, T. (2003). Intracellularly expressed single-domain antibody against p15 matrix protein prevents the production of porcine retroviruses. Journal of Virology. Retrieved from