Understanding the biology behind depression has a long history in research. To date, no unique marker or specific etiological factor was detected. However, we know more about the possible mechanisms that predispose depression or affect clinical presentation and prognosis of depression. In this thesis, we studied various hypotheses to extend our knowledge about biological determinants of depression using an epidemiological approach.

The main aims of this thesis were
1) to scrutinize the determinants and the genetic control of different functions of the HPA axis, a well-known neurohormonal correlate of depression,
2) to revisit the vascular depression hypothesis and explored the associations of non-clinical cerebrovascular alterations with depression, and
3) to explore genetic etiology of depression using the genome-wide association approach.

Additional Metadata
Keywords Depression, GWAS, HPA axis, vascular depression, epidemiology, population-based studies
Promotor A. Hofman (Albert) , H.W. Tiemeier (Henning)
Publisher Erasmus University Rotterdam
ISBN 978-94-6361-025-4
Persistent URL hdl.handle.net/1765/102772
Note The work described in this thesis was performed within the framework of the Rotterdam Study at the Department of Epidemiology of the Erasmus Medical Center, Rotterdam, the Netherlands.
Direk, N. (2017, November 14). Biological Determinants of Depression: An epidemiological approach. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/102772