A subpopulation of patients with bipolar disorder type I (BD-I) might suffer from undiagnosed autoimmune encephalitis. We tested plasma of 104 BD-I patients with a current or recent manic episode in the past 2 years for the presence of neuronal autoantibodies using immunohistochemistry, immunocytochemistry and cell-based assay (CBA). Neuronal antibodies were not detected in any of the BD type I. This finding suggests that the frequency of an undiagnosed autoimmune encephalitis in patients with BD I is less than 1%. However, these findings need to be confirmed in cerebrospinal fluid and/or blood of acutely ill manic patients.

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Keywords Antibodies, Autoimmune, Bipolar disorder, Encephalitis, Immunology, Mania
Persistent URL dx.doi.org/10.1016/j.psychres.2017.10.043, hdl.handle.net/1765/102838
Journal Psychiatry Research
Snijders, G. (Gijsje), Titulaer, M.J, Bergink, V, Bastiaansen, A.E. (Anna E.), Schreurs, M.W.J, Ophoff, R.A, … de Witte, L. (2018). No neuronal autoantibodies detected in plasma of patients with a bipolar I disorder. Psychiatry Research, 259, 460–462. doi:10.1016/j.psychres.2017.10.043