Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

Additional Metadata
Persistent URL dx.doi.org/10.1038/nature24284, hdl.handle.net/1765/102839
Journal Nature: international weekly journal of science
Grant This work was funded by the European Commission 7th Framework Programme; grant id h2020/633784 - Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST), This work was funded by the European Commission 7th Framework Programme; grant id fp7/223175 - Collaborative Oncological Gene-environment Study (COGS)
Citation
Michailidou, K. (Kyriaki), Lindström, S. (Sara), Dennis, J. (Joe), Beesley, J, Hui, S. (Shirley), Kar, S, … Easton, D.F. (2017). Association analysis identifies 65 new breast cancer risk loci. Nature: international weekly journal of science, 551(7678), 92–94. doi:10.1038/nature24284