This thesis aims to identify leukemia-specific processes that can be used to target leukemic cells or the leukemic microenvironment.

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Keywords Pediatric, Acute lymphoblastic leukemia, ALL, B-ALL, BCP-ALL, Targeted therapy, Selective targeting, Molecular drivers of leukemia, Pathobiology, Intrinsic characteristic(s), Extrinsic signal(s), PI3K, PKB / Akt, ETV6-RUNX1, TEL-AML1, Autophagy, Vps34, Autophagy inhibitors, Drug resistance, Chemotherapy resistance, L-Asparaginase resistance, Prednisolone resistance, LARG, ARHGEF 12, Migration, Leukemic niche, Bone marrow microenvironment, Leukemic microenvironment, Small molecule inhibition, CXCL12, CXCR4, Crosstalk, Tunneling nanotube(s), Mesenchymal stromal cell(s), IP10 / CXCL10, IL8 / CXCL8, MCP-1 / CCL2, CCR4, CXCR1, CXCR2, Ligands, Leukemic niche disruption
Promotor M.L. den Boer (Monique) , R. Pieters (Rob) , M. Buitenhuis (Miranda) , M. Bierings (Marc)
Publisher Erasmus University Rotterdam
ISBN 978-94-6233-805-0
Persistent URL
Polak, R. (2017, November 22). Molecular Drivers of Pediatric Acute Lymphoblastic Leukemia : Toward targeted therapy for children with ALL. Erasmus University Rotterdam. Retrieved from