Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-β collaborates with GM-CSF to induce the master transcription factor PPARγ to drive alveolar macrophage differentiation and maintenance early in life. Tissue-resident macrophages shape the development and homeostasis of the organs that they colonize. Yu et al. (2017) demonstrate that, unique to the lung, the instructive cytokine TGF-β collaborates with GM-CSF to induce the master transcription factor PPARγ to drive alveolar macrophage differentiation and maintenance early in life.

Additional Metadata
Persistent URL dx.doi.org/10.1016/j.immuni.2017.11.005, hdl.handle.net/1765/103043
Journal Immunity
Citation
Lambrecht, B.N.M. (2017). TGF-β Gives an Air of Exclusivity to Alveolar Macrophages. Immunity, 47(5), 807–809. doi:10.1016/j.immuni.2017.11.005