We report a 36-year-old woman with primary hypothyroidism revealed by postpartum amenorrhoea-galactorrhoea associated with hyperprolactinaemia and suprasellar pituitary enlargement on magnetic resonance imaging (MRI). On thyroid hormone replacement therapy all clinical, biochemical, radiological and endocrine abnormalities disappeared. Hyperplasia of pituitary thyrotrophs and/or lactotrophs seems to be responsible for the pituitary enlargement seen on MRI.

*Postpartum Period, Adult, Amenorrhea/*etiology, Female, Galactorrhea/*etiology, Humans, Hyperprolactinemia/*complications, Hypothyroidism/complications, Magnetic Resonance Imaging, Pituitary Gland/*pathology, Pregnancy, Thyroxine/therapeutic use
The Netherlands Journal of Medicine
Erasmus MC: University Medical Center Rotterdam

Kroese, J.M, Grootendorst, A.F, & Schelfhout, L.J. (2004). Postpartum amenorrhoea-galactorrhoea associated with hyperprolactinaemia and pituitary enlargement in primary hypothyroidism. The Netherlands Journal of Medicine. Retrieved from http://hdl.handle.net/1765/10329