OBJECTIVE Primary aim: to determine the prevalence of bleedings and thrombotic events in anticoagulants users during hospitalization. Secondary aims: to determine the type and location and the potential risk factors that are associated with bleedings and thrombotic events. DESIGN zProspective, observational, multicenter cohort study. METHODS The study was performed at the Erasmus MC, Rotterdam and the Reinier de Graaf hospital. Delft. Patients who were treated with anticoagulants were included in the study. Exclusion criteria were hospitalization of less than 24 hours, admission to the Intensive care unit without admission to another, regular hospital department, and patients treated with low-molecular-weight heparins only for thrombosis prophylaxis. RESULTS We included 942 patients. The prevalence of in-hospital bleeding events was 8.8%, of which 44% were surgical site bleedings. The prevalence of thrombotic events during hospitalization was 0.7%. Multivariate logistic regression analysis Indicated that female gender (odds ratio [OR] 1.82; 95% confidence interval [95% CI] 1.11-2.991. age 70 years or older (OR 1.73; 95% C11.03-2.89), hospitalization of five days or longer (OR 2.86; 95% CI 1.43-5.721, admission to the academic hospital (OR 1.93; 95% C11.12-3.34) and admission to surgical wards (OR 1.98; 95% C11.20-3.73) were associated with more bleeding events. We found no potential risk factors associated with thrombotic events, as the number of cases was very small. CONCLUSION Bleeding events occurred in 8.8%, thrombotic events in 0.7% of anticoagulants users during hospitalization. Female gender, age 70 years or older, hospitalization of 5 days or longer, admission to the academic hospital and admission to surgical wards seem to be risk factors.

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Persistent URL hdl.handle.net/1765/103382
Journal Pharmaceutisch Weekblad
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Dreijer, A.R. (A. R.), Diepstraten, J, Kruip, M.J.H.A, Brouwer, R.E, Leebeek, F.W.G, & Bemt, R.M.L.A. van den. (2017). Prevalentie en aard van bloedingen en tromboses en geassocieerde risicofactoren tijdens de ziekenhuis-opname bij patiënten die anticoagulantia gebruiken. Pharmaceutisch Weekblad, 152(46), 17–20. Retrieved from http://hdl.handle.net/1765/103382