The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis
Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease.
Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4. years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5-7. years were investigated. Models were adjusted for multiple markers of disease severity at baseline.
Results: De novo S. aureus acquisition at 3-years-old (n/N=12/122) was associated with increased bronchiectasis score at age 5-6years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25-75 at age 5-7years, but not with FEV1-%-predicted.
Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25-75 in children with CF.
|Keywords||CT scan, Infection and inflammation, Lung function, Structural lung damage|
|Persistent URL||dx.doi.org/10.1016/j.jcf.2017.12.002, hdl.handle.net/1765/103633|
|Journal||Journal of Cystic Fibrosis|
Caudri, D, Turkovic, L, Ng, J. (Jolyn), de Klerk, N.H, Rosenow, T, Hall, G.L, … Stick, S. (2017). The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis. Journal of Cystic Fibrosis. doi:10.1016/j.jcf.2017.12.002