In an elegant publication in Cell Research, Tan and colleagues showed that ablation of PRRT2 in cerebellar granule cells is sufficient to induce paroxysmal kinesigenic dyskinesia. PRRT2 turns out to downregulate the presynaptic SNARE complex in granule cell axons, which in turn controls the activity patterns of Purkinje cells, the sole output of the cerebellar cortex.

Additional Metadata
Persistent URL,
Journal Cell Research
Kros, L, & de Zeeuw, C.I. (2018). PRRT2-dependent dyskinesia: Cerebellar, paroxysmal and persistent. Cell Research, 28(1), 3–4. doi:10.1038/cr.2017.142