DNA is constantly damaged by various genotoxic agents from both external and internal sources and this has severe adverse effects on key cellular processes as transcription and replication, thereby negatively influencing cell viability.
To maintain genome integrity, these harmful effects are counteracted by the DNA damage response (DDR), a complex network consisting of several signaling pathways and DNA repair mechanisms. [...]

Additional Metadata
Keywords DNA damage, histones, post translation modifications, chromatin remodeling, UV, histone chaperones, transcription, Trichothiodystrophy, ubiquitin, acetylation, SET, TFIIEβ
Promotor W. Vermeulen (Wim) , J.A. Marteijn (Jurgen)
Publisher Erasmus University Rotterdam
ISBN 978-94-6295-807-4
Persistent URL hdl.handle.net/1765/104021
Citation
Mandemaker, I.K. (2018, January 24). Unraveling the Chromatin in the DNA Damage Response. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/104021