DNA is constantly damaged by various genotoxic agents from both external and internal sources and this has severe adverse effects on key cellular processes as transcription and replication, thereby negatively influencing cell viability.
To maintain genome integrity, these harmful effects are counteracted by the DNA damage response (DDR), a complex network consisting of several signaling pathways and DNA repair mechanisms. [...]

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W. Vermeulen (Wim) , J.A. Marteijn (Jurgen)
Erasmus University Rotterdam
Department of Molecular Genetics

Mandemaker, I. (2018, January 24). Unraveling the Chromatin in the DNA Damage Response. Retrieved from http://hdl.handle.net/1765/104021