Association of genetic risk for schizophrenia and bipolar disorder with infant neuromotor development

Schizophrenia and bipolar disorder (BD) are heritable disorders with similarities in clinical symptoms and typical onset after puberty. While research shows that impaired motor coordination can have an associationwith schizophrenia, there are limited data on childhood development preceding BD. Murray et al proposed a developmental model for similarities and dissimilarities between schizophrenia and BD, but it remains unknown if dissimilarities exist in early infancy and if they covary with genetic liability for these disorders. Using polygenic risk scores (PRSs),we exploredwhether genetic risk for schizophrenia and genetic risk for BD are associated with neuromotor development in infancy.

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