Development of Novel Anti-viral Strategies for Hepatitis E

The main aims of this thesis are:
(1) to investigate the regulatory mechanisms of IFN-stimulated genes and the resulting antiviral effects against HEV (Part I, Chapter 3-7),
(2) to evaluate the effects of direct-acting antiviral drugs or compounds for HEV (Part II, Chapter 8-11),
(3) to dissect virus-host interactions between HEV and host cells (Part III, Chapter 12-15). As will become evident, these efforts have yielded progress and novel insights in all three of these issues and thus may help develop novel relational therapeutic avenues of dealing with HEV infection.