Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Symptoms of MS include cognitive, motoric, sensory and visual impairment, pain and fatigue. The genetic background of the host and infection with the herpesvirus family member Epstein-Barr virus (EBV) are risk factors for developing MS but the pathogenic mechanisms are unknown. In this thesis we set out to clarify the putative role of EBV in MS by analyzing the intrathecal viral prevalence, breadth and magnitude of humoral and cellular EBV-specific immune responses and autoimmune responses in MS patients.

Multiple sclerosis, clinically isolated syndrome, Epstein-Barr virus, human herpesvirus, central nervous system, chronic inflammation, white matter lesion, cerebrospinal fluid, normal appearing white matter, autoimmunity, antigen discovery, genetic risk variants, T-cell phenotype, T-cell function, T-cell differentiation, cytotoxic T-cells, humoral immune responses, intrathecal immunity, latent infection, lytic cycle infection, Epstein-Barr virus nuclear antigen 1, EBNA-1
R.Q. Hintzen (Rogier) , G.M. Verjans (Georges M.)
Erasmus University Rotterdam
Department of Neurology

van Nierop, G.P. (2018, February 7). Recognition of Epstein-Barr Virus in Multiple Sclerosis. Erasmus University Rotterdam. Retrieved from