Scientific advancement and advancements in information technology have increased our capability for sharing information, and spreading scientific discoveries throughout society. In the past decade the Dutch government has been trying to stimulate the knowledge economy through various means. Among them the stimulation of the founding of the Dutch Centres for Entrepreneurship, and the Valorisation programme. However, over the years, publication volume has become the main indicator for being a successful scientist. This focus on publications and research disincentivizes scientists from activities that generate more concrete value for society. The Societal Impact Value Cycle seeks to offer scientists and others a toolbox for visualising and understanding the way innovation can be fostered, and how other processes can foster scientific research in return. It also maps the way by which an innovation ecosystem generates socio-economic value from academic activities. It should be noted that not all scientific research leads to innovations that generate value for society, and not all research is intended to change the course of events. Nonetheless, fostering cooperation between research institutes and societal stakeholders, and increasing awareness of how entrepreneurial skills and activities could not only lead to a return on investments necessary for scientific advancement, but also increase the societal impact from academic endeavours. This could benefit our society, and societies worldwide, both socially and economically. This publication will offer valuable insight and an effective toolbox for people interested in socio-economic value creation from scientific research, or, in other words, valorisation. Therewith, it lays at the heart of Stichting Maatschappij en Onderneming’s daily occupations and our close cooperation with the Erasmus University Rotterdam.