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Goetz, M.P. (Matthew P.), K. Sangkuhl, H.J. Guchelaar (Henk Jan), M. Schwab (Matthias), Province, M. (Michael), M. Whirl-Carrillo, Symmans, W.F. (W. Fraser), H.L. McLeod (Howard), Ratain, M.J. (Mark J.), Zembutsu, H. (Hitoshi), et al. A. Gaedigk, R.H.N. van Schaik (Ron), J.N. Ingle (J.), K. Caudle and T.E. Klein (T.)

2018

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Publication

Publication

Clinical Pharmacology and Therapeutics

Tamoxifen is biotransformed by CYP2D6 to 4-hydroxytamoxifen and 4-hydroxy N-desmethyl tamoxifen (endoxifen), both with greater antiestrogenic potency than the parent drug. Patients with certain CYP2D6 genetic polymorphisms and patients who receive strong CYP2D6 inhibitors exhibit lower endoxifen concentrations and a higher risk of disease recurrence in some studies of tamoxifen adjuvant therapy of early breast cancer. We summarize evidence from the literature and provide therapeutic recommendations for tamoxifen based on CYP2D6 genotype.

Additional Metadata
Persistent URL doi.org/10.1002/cpt.1007, hdl.handle.net/1765/104402
Journal Clinical Pharmacology and Therapeutics
Grant This work was funded by the European Commission 7th Framework Programme; grant id h2020/668353 - Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen (U-PGx)
Organisation Erasmus MC: University Medical Center Rotterdam
Citation
Goetz, M.P. (Matthew P.), Sangkuhl, K., Guchelaar, H. J., Schwab, M., Province, M. (Michael), Whirl-Carrillo, M., … Klein, T. (2018). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy. Clinical Pharmacology and Therapeutics. doi:10.1002/cpt.1007


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