2018-02-01
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent
Publication
Publication
Molecular Nutrition & Food Research (Print) , Volume 62 - Issue 3
Scope: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. Methods and results: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10−7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3’ of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10−8) such that each serving of low-fat dairy was associated with 0.225 kg m−2 lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure. Conclusion: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
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| doi.org/10.1002/mnfr.201700347, hdl.handle.net/1765/104481 | |
| Molecular Nutrition & Food Research (Print) | |
| Organisation | Department of Epidemiology |
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Smith, C., Follis, J., Dashti, H. S., Tanaka, T. (Toshiko), Graff, M. J. L., Fretts, A. M., … Ordovás, J.M. (José M.). (2018). Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Molecular Nutrition & Food Research (Print), 62(3). doi:10.1002/mnfr.201700347 |
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