Purpose: To determine if use of antiplatelet or anticoagulant (AP/AC) medication influences visual acuity in patients with active neovascular age-related macular degeneration (N-AMD). Design: Retrospective analysis of data from a randomized controlled trial.
Methods: SETTING: Multicenter.
STUDY POPULATION: Total of 330 patients with active N-AMD from the BRAMD study, a comparative trial between bevacizumab and ranibizumab in the Netherlands.
OBSERVATION PROCEDURES: Patients underwent an extensive ophthalmic examination. Visual acuity was categorized into functional vision (best-corrected visual acuity [BCVA] ≥ 0.5), visual impairment (BCVA < 0.5), and severe visual impairment (BCVA < 0.3). Fundus photographs were graded for presence of retinal or subretinal hemorrhages. Information on AP/AC medication was obtained through interview. Logistic regression analysis was used to determine associations between AP/AC medication and outcomes. Frequency of hemorrhages in users and non-users stratified for visual acuity categories was analyzed with ANCOVA.
MAIN OUTCOME MEASURES: BCVA and presence of hemorrhages. Results: In total, 40.9% of the patients used AP/AC medication, of which 73.3% was aspirin. AP/AC use was not associated with visual impairment (adjusted odds ratio [OR] 0.79; 95% confidence interval [CI] 0.43-1.44) or severe visual impairment (adjusted OR 0.75; 95% CI 0.40-1.43). Patients on AP/AC presented with comparable frequencies of hemorrhages (27% vs 32%, P =.32, respectively). Similar results were found when analyses were restricted to aspirin users only. Conclusion: In our study, use of AP/AC medication was associated neither with visual decline nor with the occurrence of hemorrhages in patients with active N-AMD.

Additional Metadata
Contributor The Comparing Bevacizumab to Ranibizumab in Age-related Macular Degeneration (BRAMD) Trial Research Group
Persistent URL dx.doi.org/10.1016/j.ajo.2018.01.003, hdl.handle.net/1765/104501
Journal American Journal of Ophthalmology
Note on behalf of The Comparing Bevacizumab to Ranibizumab in Age-related Macular Degeneration (BRAMD) Trial Research Group
Citation
Buitendijk, G.H.S, Schauwvlieghe, A.M.E, Vingerling, J.R, Schlingemann, R.O, & Klaver, C.C.W. (2018). Antiplatelet and Anticoagulant Drugs Do Not Affect Visual Outcome in Neovascular Age-Related Macular Degeneration in the BRAMD Trial. American Journal of Ophthalmology, 187, 130–137. doi:10.1016/j.ajo.2018.01.003