Delirium in Old Age : Pathophysiological and Pharmacological Aspects

Delirium, an acute neuropsychiatric syndrome, affects approximately 1 out of 3 older patients admitted to the hospital and is associated with poor outcomes, including increased rates of postdischarge institutionalization, cognitive decline and mortality. Approximately 20 to 25% of the patients who experience delirium dies within 6 to 12 months. Despite the high prevalence and clinical impact, very little is known about the underlying pathogenesis.
In this thesis, we have investigated potential novel biomarkers of delirium and the role of pharmacological agents in the development of delirium. The findings may contribute to a better understanding of the pathophysiology and may help to improve the prediction, detection and treatment of this syndrome.