Trapped in the Matrix: Neutrophil Extracellular Traps (NETs) and Fibrin in Wound Healing
Gevangen in de Matrix: Neutrophil Extracellular Traps (NETs) en Fibrine in Wondgenezing
The aim of this thesis was to investigate the effect of fibrin, NETs and the induction of NETosis, in wound healing. To achieve this, we created in vitro models to study the formation of NETs by several inducers, such as PMA, LPS, S. aureus, E. coli and N. meningitidis.
Furthermore, we studied the role of NETs and extracellular DNA in sepsis and thrombosis. A diabetic rat model was used to study the effect of fibrin on wound healing.
|Keywords||Neutrophil Extracellular Traps, NETs, NETosis, Fibrin, Wound Healing, Diabetes, Matrix, Sepsis, S. aureus, Straphylococcus aureus, Protein A, SpA, biofilm, FH, Factor H, VWF, von Willebrand factor, thrombosis|
|Promotor||F.W.G. Leebeek (Frank) , J.W. van Neck (Han) , M.P.M. de Maat (Moniek)|
|Publisher||Erasmus University Rotterdam|
|Sponsor||This thesis was funded by grants from the Nuts Ohra Foundation and Stichting Coolsingel|
Hoppenbrouwers, T. (2018, March 7). Trapped in the Matrix: Neutrophil Extracellular Traps (NETs) and Fibrin in Wound Healing. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/104725