The aim of this thesis was to investigate the effect of fibrin, NETs and the induction of NETosis, in wound healing. To achieve this, we created in vitro models to study the formation of NETs by several inducers, such as PMA, LPS, S. aureus, E. coli and N. meningitidis.
Furthermore, we studied the role of NETs and extracellular DNA in sepsis and thrombosis. A diabetic rat model was used to study the effect of fibrin on wound healing.

Additional Metadata
Keywords Neutrophil Extracellular Traps, NETs, NETosis, Fibrin, Wound Healing, Diabetes, Matrix, Sepsis, S. aureus, Straphylococcus aureus, Protein A, SpA, biofilm, FH, Factor H, VWF, von Willebrand factor, thrombosis
Promotor F.W.G. Leebeek (Frank) , J.W. van Neck (Han) , M.P.M. de Maat (Moniek)
Publisher Erasmus University Rotterdam
Sponsor This thesis was funded by grants from the Nuts Ohra Foundation and Stichting Coolsingel
ISBN 978-94-6295-854-8
Persistent URL
Hoppenbrouwers, T. (2018, March 7). Trapped in the Matrix: Neutrophil Extracellular Traps (NETs) and Fibrin in Wound Healing. Erasmus University Rotterdam. Retrieved from