Antinuclear antibodies (ANA) are antibodies directed against a variety of nuclear antigens and are detected in patients with autoimmune diseases. Antinuclear antibodies (ANA) profiling is relevant for diagnostic purposes in various diseases, including systemic lupus erythematosus (SLE), Sj€ogren syndrome and systemic sclerosis (Smeenk et al. 1990; Hamaguchi 2010). In the past, ANA were also determined in all patients with uveitis for diagnostic screening purposes; however, this approach has been abandoned as its relevance in adult patients with uveitis was shown to be limited (Murray 1986). In the last decades, analysis of ANA has greatly improved and various subtypes and staining patterns are currently appreciated. Therefore, this study aimed to assess the presence, subtypes and titres of ANA in adult patients with uveitis of different aetiologies and re-evaluate its possible value for diagnostic screening in uveitis. [...]