Intra- and inter-cellular signaling pathways have become promising candidates for cancer therapy, because they are frequently affected by oncogenic aberrations and specific small molecule inhibitors are available.
The aim of this thesis is to identify and evaluate signaling pathways that may be targeted by novel therapeutic approaches in children with BCP-ALL.

Additional Metadata
Keywords Pediatric acute lymphoblastic leukemia, targeted therapy, JAK2, RAS, PDGFRA, FGFR, EMP-1
Promotor M.L. den Boer (Monique) , R. Pieters (Rob)
Publisher Erasmus University Rotterdam
ISBN 978-94-6295-845-6
Persistent URL
Jerchel, I.S. (2018, March 14). Signaling Pathways as Therapeutic Targets in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia. Erasmus University Rotterdam. Retrieved from