Patient Outcomes in the Treatment of Rheumatoid Arthritis : Informing tapering decisions
Patiëntgebonden factoren bij de behandeling van reumatoïde artritis : relatie met opbouw en afbouw van medicatie
Despite the advances that have been made in the medical treatment of Rheumatoid arthritis (RA), challenges to further optimize care for patients remain. Two of these challenges will be the focus of this work:
First, despite the better medical outcomes the burden of disease in RA patients is still higher compared to the general population, which may be attributed, at least in part, to higher levels of psychological distress patients experience.
Second, continuous medical drug treatment for patients in remission is only justified if the benefits outweigh the disadvantages such as potential overtreatment, safety considerations and treatment costs.
These challenges resulted in the main objectives of this thesis:
1. To study the impact of psychosocial factors on patients with early RA, with special interest in the relationships between psychosocial factors and disease activity score and achievement of treatment goals
2. To study the effects of treatment de-escalation in patients with low disease activity or remission and aid rheumatologists in making informed decisions with regard to treatment de-escalation
|Keywords||Rheumatoid Arthritis, disease activity score (DAS), psychosocial aspects, depression, anxiety, fatigue, coping, health related quality of life, tapering, remission, treatment de-escalation, disease modifying anti-rheumatic drugs (DMARDs), TNF-inhibitors, biologicals, discrete choice experiment (DCE), systematic review|
|Promotor||J.M.W. Hazes (Mieke) , J.J. Luime (Jolanda) , A.E.A.M. Weel (Angelique)|
|Publisher||Erasmus University Rotterdam|
Kuijper, T.M. (2018, March 20). Patient Outcomes in the Treatment of Rheumatoid Arthritis : Informing tapering decisions. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/104843