The aim of this study is to evaluate the reliability, validity, and acceptability of the Chinese version of the EORTC QLQ-OES18 in patients with esophageal cancer. The questionnaire was translated according to the guideline of the EORTC. One hundred and forty-nine patients with esophageal cancer from Tianjin Medical University Cancer Institute and Hospital completed the Karnofsky performance scale (KPS) and the simplified Chinese EORTCQLQ-C30/OES18 scales during July 2013 to January 2014. The results were statistically analyzed by Cronbach's α coefficient, Spearman correlation test with multiple strengthen analysis, and Wilcoxon Rank Sum test. The internal consistency (Cronbach's α coefficient) of all four scales (dysphagia, eating, reflux, and pain) was 0.689-0.822, which were satisfactory or near satisfactory. The absolute values of correlation of each scale between EORTC QLQ-OES18 and EORTC QLQ-C30 were 0.002-0.750 while there was no significant difference between groups divided by KPS scores. We confirmed the Chinese version of EORTC QLQ-OES18 appears to be a reliable, valid, and acceptable instrument for measuring the health-related quality of life of patients with esophageal cancer in mainland China.

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Keywords EORTC QLQ-C30, EORTC QLQ-OES18, Esophageal cancer, Quality of life, Validation
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Journal Diseases of the Esophagus
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Dai, Z. (Z.), Lang, W. (W.), Yang, H. (H.), Tian, J. (J.), Sun, W. (W.), Pekbay, B, … Zhang, L. (2017). Validation of EORTC QLQ-OES18 for Chinese patients with esophageal cancer. Diseases of the Esophagus, 30(10), 1–7. doi:10.1093/dote/dox046