Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

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Keywords Enterococcus faecium, Genomic island, Vancomycin resistance, VanD type
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Journal Antimicrobial Agents and Chemotherapy
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Grant This work was funded by the European Commission 7th Framework Programme; grant id erc/742158 - Scalable inference algorithms for Bayesian evolutionary epidemiology (SCARABEE)
Top, J, Sinnige, J.C. (Jan C.), Brouwer, E.C, Werner, G. (Guido), Corander, J, Severin, J.A, … Willems, R.J.L. (2018). Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates. Antimicrobial Agents and Chemotherapy, 62(3). doi:10.1128/AAC.01793-17