2018-03-01
Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates
Publication
Publication
Antimicrobial Agents and Chemotherapy
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Volume 62
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Issue 3
Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.
| Additional Metadata | |
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| Keywords | Enterococcus faecium, Genomic island, Vancomycin resistance, VanD type |
| Persistent URL | dx.doi.org/10.1128/AAC.01793-17, hdl.handle.net/1765/104888 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Grant | This work was funded by the European Commission 7th Framework Programme; grant id erc/742158 - Scalable inference algorithms for Bayesian evolutionary epidemiology (SCARABEE) |
| Citation |
Top, J, Sinnige, J.C. (Jan C.), Brouwer, E.C, Werner, G. (Guido), Corander, J, Severin, J.A, … Willems, R.J.L. (2018). Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates. Antimicrobial Agents and Chemotherapy, 62(3). doi:10.1128/AAC.01793-17
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