Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Enterococcus faecium, Genomic island, Vancomycin resistance, VanD type,
Antimicrobial Agents and Chemotherapy
This work was funded by the European Commission 7th Framework Programme; grant id erc/742158 - Scalable inference algorithms for Bayesian evolutionary epidemiology (SCARABEE)
Department of Medical Microbiology and Infectious Diseases

Top, J, Sinnige, J.C. (Jan C.), Brouwer, E.C, Werner, G. (Guido), Corander, J, Severin, J.A, … Willems, R.J.L. (2018). Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates. Antimicrobial Agents and Chemotherapy, 62(3). doi:10.1128/AAC.01793-17