Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice
Hydrogen sulfide (H2S, 80 ppm) gas in an atmosphere of 17.5% oxygen reportedly induces suspended animation in mice; a state analogous to hibernation that entails hypothermia and hypometabolism. However, exogenous H2S in combination with 17.5% oxygen is able to induce hypoxia, which in itself is a trigger of hypometabolism/hypothermia. Using non-invasive thermographic imaging, we demonstrated that mice exposed to hypoxia (5% oxygen) reduce their body temperature to ambient temperature. In contrast, animals exposed to 80 ppm H2S under normoxic conditions did not exhibit a reduction in body temperature compared to normoxic controls. In conclusion, mice induce hypothermia in response to hypoxia but not H2S gas, which contradicts the reported findings and putative contentions.
|Persistent URL||dx.doi.org/10.1038/s41598-018-21729-8, hdl.handle.net/1765/105079|
Hemelrijk, S.D. (Sebastiaan D.), Dirkes, M.C. (Marcel C.), van Velzen, M.H.N, Bezemer, R, van Gulik, T.M, & Heger, M. (2018). Exogenous hydrogen sulfide gas does not induce hypothermia in normoxic mice. Scientific Reports, 8(1). doi:10.1038/s41598-018-21729-8