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K. Geneugelijk (Kirsten), Niemann, M. (Matthias), J. Drylewicz (Julia), van Zuilen, A.D. (Arjan D.), I. Joosten (Irma), W.A. Allebes (Wil), A. van der Meer, L.B. Hilbrands (Luuk), M.C. Baas (Marije), C.E. Hack (Erik), et al. F. van Reekum, M.C. Verhaar (Marianne), E.G. Kamburova, Bots, M.L. (Michiel L.), M.A.J. Seelen, J.S.F. Sanders, B.G. Hepkema (Bouke), A.J.A. Lambeck (Annechien J.A.), L.B. Bungener, C. Roozendaal, M.G.J. Tilanus (Marcel), J. Vanderlocht (Joris), C.E.M. Voorter (C. E M), L. Wieten, E. van Duijnhoven, M. Gelens, M.H. Christiaans (Maarten), F. van Ittersum, A. Nurmohamed, Lardy, J.N.M. (Junior N.M.), W.T. Swelsen, K.A. van der Pant, N.C. van der Weerd (Neelke), I.J.M. ten Berge (Ineke), F.J. Bemelman (Fréderike), A.J. Hoitsma (Andries), P.J.M. van der Boog, J.W. de Fijter (Johan), M.G.H. Betjes (Michiel), P.J. Heidt (Peter), D.L. Roelen (Dave), F.H.J. Claas (Frans), H.G. Otten (Henderikus) and E. Spierings (E.)

2018-03-05

PIRCHE-II is related to graft failure after kidney transplantation

Publication

Publication

Frontiers in Immunology , Volume 9 - Issue MAR

Individual HLA mismatches may differentially impact graft survival after kidney transplantation. Therefore, there is a need for a reliable tool to define permissible HLA mismatches in kidney transplantation. We previously demonstrated that donor-derived Predicted Indirectly ReCognizable HLA Epitopes presented by recipient HLA class II (PIRCHE-II) play a role in de novo donor-specific HLA antibodies formation after kidney transplantation. In the present Dutch multi-center study, we evaluated the possible association between PIRCHE-II and kidney graft failure in 2,918 donor-recipient couples that were transplanted between 1995 and 2005. For these donors-recipients couples, PIRCHE-II numbers were related to graft survival in univariate and multivariable analyses. Adjusted for confounders, the natural logarithm of PIRCHE-II was associated with a higher risk for graft failure [hazard ratio (HR): 1.13, 95% CI: 1.04-1.23, p = 0.003]. When analyzing a subgroup of patients who had their first transplantation, the HR of graft failure for ln(PIRCHE-II) was higher compared with the overall cohort (HR: 1.22, 95% CI: 1.10-1.34, p < 0.001). PIRCHE-II demonstrated both early and late effects on graft failure in this subgroup. These data suggest that the PIRCHE-II may impact graft survival after kidney transplantation. Inclusion of PIRCHE-II in donor-selection criteria may eventually lead to an improved kidney graft survival.

Additional Metadata
Keywords Graft rejection, HLA antigens, HLA matching, Kidney transplantation, PIRCHE-II
Persistent URL doi.org/10.3389/fimmu.2018.00321, hdl.handle.net/1765/105085
Journal Frontiers in Immunology
Organisation Department of Internal Medicine
Citation
Geneugelijk, K., Niemann, M. (Matthias), Drylewicz, J., van Zuilen, A.D. (Arjan D.), Joosten, I., Allebes, W., … Spierings, E. (2018). PIRCHE-II is related to graft failure after kidney transplantation. Frontiers in Immunology, 9(MAR). doi:10.3389/fimmu.2018.00321
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