The pathophysiology of affective disorders is largely unknown. In patients with various affective disorders the activity of pterins and related amino acids were investigated before and after clinical treatment. In particular the bipolar affective disorder could be characterized by less activity of tetrahydrobiopterin resulting in decreased synthesis of nitric oxide. After clinical recovery the same results were seen implicating that disturbances in the pterin metabilism could reflect a vulnerability for mood disorders.

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Keywords arginine, bipolar disorder, depression, electroconvulsive therapy, mania, nepterin, nitric oxide, seasonal affective disorder, tetrahydrobiopterin
Promotor W.M.A. Verhoeven (Wim)
Publisher Erasmus University Rotterdam
Sponsor StichtingJos Schaap-Feering, Rotterdam, the Netherlands, Verhoeven,. Prof. Dr. W.M.A. (promotor
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Note Chapter 2 "Nitric oxide and neopterin in bipolar affective disorder" was originally published in: Neuropsychobiology 2006; 54: 75-81 (Kaerger,
Hoekstra, R. (2007, September 19). Pterins and affective disorders. Erasmus University Rotterdam. Retrieved from