Four cancer cases after esophageal atresia repair
Time to start screening the upper gastrointestinal tract
World Journal of Gastroenterology , Volume 24 - Issue 9 p. 1056- 1062
Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia (72%) and gastroesophageal reflux (GER) (67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett’s esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett’s esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients.
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|World Journal of Gastroenterology|
|Organisation||Department of Gastroenterology & Hepatology|
Vergouwe, F.W.T, Gottrand, M. (Madeleine), Wijnhoven, B.P.L, IJsselstijn, H, Piessen, G. (Guillaume), Bruno, M.J, … Spaander, M.C.W. (2018). Four cancer cases after esophageal atresia repair. World Journal of Gastroenterology, 24(9), 1056–1062. doi:10.3748/wjg.v24.i9.1056