Uremia-associated premature T-cell ageing contributes to a defective T cell-mediated immune system in End-stage renal disease (ESRD) patients. A comprehensive more in depth evaluation of defective T cell-mediated immune system, taking functional aspects into account, in ESRD patients is crucial to identify patients at risk for infections, virus-related cancers, and decreased vaccination efficacy and allograft rejection.
In this thesis, a more detailed assessment of the defective T-cell mediated immune system, studying both phenotypic as well as functional aspects, in ESRD patients is described. Special emphasis is put on the increasing population of elderly ESRD patients.

C.C. Baan (Carla) , M.G.H. Betjes (Michiel) , N.H.R. Litjens (Nicolle)
Erasmus University Rotterdam
Department of Internal Medicine

Huang, L. (2018, April 18). New insights in the T-cell immune system of end-stage renal disease patients. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/105349