1998-03-01
Internalization of radiolabelled [dtpa0]octreotide and [dota0, tyr3]octreotide peptides for somatostatin receptor-targeted scintigraphy and radionuclide therapy
Publication
Publication
Nuclear Medicine Communications , Volume 19 - Issue 3 p. 283- 288
We compared the internalization of [90Y-DOTA0, Tyr3]octreotide and [111In-DOTA0, Tyr3]octreotide with that of [125I-Tyr3]octreotide and [111In-DTPA0]octreotide in the subtype 2 somatostatin receptor (sst2)-positive rat pancreatic tumour cell lines Ca20948 and AR42) and in the somatostatin receptor-negative human anaplastic thyroid tumour cell line ARO. We demonstrated that [111In-DTPA0]octreotide, [90Y-DOTA0, Tyr3]octreotide and [111In-DOTA0, Tyr3]octreotide are internalized by a receptor-specific, time- and temperature-dependent process. The amount of [90Y-DOTA0, Tyr3]octreotide internalized was higher than that of [111In-DOTA0, Tyr3]octreotide and [111In-DTPA0]octreotide.
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| doi.org/10.1080/00006231-199803000-00013, hdl.handle.net/1765/105562 | |
| Nuclear Medicine Communications | |
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de Jong, M., Bernard, B., Bruin, E.C. (Eric), van Gameren, A., Bakker, W., Krenning, E., … Mäcke, H. (1998). Internalization of radiolabelled [dtpa0]octreotide and [dota0, tyr3]octreotide peptides for somatostatin receptor-targeted scintigraphy and radionuclide therapy. Nuclear Medicine Communications, 19(3), 283–288. doi:10.1080/00006231-199803000-00013 |
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