Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24-25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from-0.27 to-0.47), except for the temporal outer (r =-0.15, P = 0.089) and inferior outer (r =-0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.

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Journal Scientific Reports
Qiu, K. (Kunliang), Wang, G. (Geng), Zhang, R. (Riping), Lu, X. (Xuehui), Zhang, M. (Mingzhi), & Jansonius, N.M. (2018). Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes. Scientific Reports, 8(1). doi:10.1038/s41598-018-23479-z